Clinical Indication ID & Name
Prostate Cancer
Test Group
Solid Tumours (Adult)
Specialties
Test code
M218.1
Test name
Multi-target NGS panel - small variant (BRCA1, BRCA2, ATM, CDK12)
Target genes
BRCA1, BRCA2, ATM, CDK12
Test scope
Small variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
NB BRCA1/2 for any prostate cancer, ATM / CDK12 for metastatic castrate resistant prostate cancer
Test code
M218.2
Test name
Multi-target NGS panel - structural variant (TMPRSS2-ERG, NTRK1, NTRK2, NTRK3)
Target genes
TMPRSS2-ERG, NTRK1, NTRK2, NTRK3
Test scope
Structural variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Only required if there is a doubt over the aetiology of a tumour on the basis of morphology and prostate carcinoma is in the differential
Test code
M218.3
Test name
TMPRSS2-ERG FISH
Target genes
TMPRSS2-ERG
Test scope
Structural variant detection
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
Only required if there is a doubt over the aetiology of a tumour on the basis of morphology and prostate carcinoma is in the differential
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH
Contact with queries
Supporting documents
n/a
Education resources
n/a
Service updates
n/a
Request form download
Consent record
See consent guidance in test request form
Sample requirements
See sample guidance in test request form