Request / Find a Test Tool

The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

This tool allows clinical teams to search all of the genomic tests available to patients through the National Testing Directory. From here you can find out more details about each test and information about how to order them. These tests can only be ordered by clinical teams, if you are a patient looking to request a test please speak to your clinical team directly.

Plasma Cell Dyscrasia

Clinical Indication ID & Name

M92

Plasma Cell Dyscrasia

Test Group

Haematology

Specialties

Test code

M92.1

Test name

Multi-target NGS panel - small variant (KRAS, NRAS, BRAF, TP53, DIS3, TENT5C, IRF4)

Target genes

KRAS, NRAS, BRAF, TP53, DIS3, TENT5C, IRF4

Test scope

Small variant detection

Test method/ technology

Panel

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.2

Test name

t(4;14) IGH-FGFR3FISH/RT-PCR

Target genes

IGH-FGFR3

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.3

Test name

t(6;14) IGH-CCND3 FISH/RT-PCR

Target genes

IGH-CCND3

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.4

Test name

t(11;14)(q13;q32) IGH-CCND1 FISH/RT-PCR

Target genes

IGH-CCND1

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.5

Test name

t(14;16) IGH-MAF FISH/RT-PCR

Target genes

IGH-MAF

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.6

Test name

t(14;20) IGH-MAFB FISH/RT-PCR

Target genes

IGH-MAFB

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.7

Test name

Multi-target NGS panel - structural variant (To include IGH-FGFR3, IGH-CCND3, IGH-CCND1, IGH-MAF, IGH-MAFB, MYC rearrangements)

Target genes

To include IGH-FGFR3, IGH-CCND3, IGH-CCND1, IGH-MAF, IGH-MAFB, MYC rearrangements

Test scope

Structural variant detection

Test method/ technology

Panel

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.8

Test name

IGH rearrangement FISH

Target genes

IGH

Test scope

Structural variant detection

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.9

Test name

Hyperdiploidy copy number FISH

Target genes

Hyperdiploidy

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.10

Test name

del(1p) copy number FISH

Target genes

del(1p) - CDKN2C

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.11

Test name

gain(1q) copy number FISH

Target genes

gain(1q) - CKS1B

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.12

Test name

del(17p) TP53 copy number FISH

Target genes

TP53

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.13

Test name

Multi-target NGS panel (To include hyperdiploidy, del(1p), gain(1q), del17p)

Target genes

Multiple chromosomes, Chr1p, Ch1q, Cr17p

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

Panel

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.14

Test name

MYC rearrangement FISH

Target genes

MYC

Test scope

Structural variant detection

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Commissioning group

n/a

Overlapping idications

n/a

Address for samples/request forms

North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH

Contact with queries

rmh-tr.moleculardiagnostics@nhs.net

Supporting documents

n/a

Education resources

n/a

Service updates

n/a

Request form download

n/a

Consent record

See consent guidance in test request form

Sample requirements

See sample guidance in test request form