Testing can be offered when paternal exclusion testing can be offered in families at risk of a recessive disorder when parents carry different mutations or where the father has an autosomal dominant mutation or is known mosaic for a mutation. NIPD should only be offered for conditions where invasive testing would otherwise be offered and following discussion with the testing laboratory.

Note: pre-pregnancy work up (R389) is required to enable confirmation that NIPD is possible and to allow timely delivery in pregnancy

Testing should be discussed in advance with the testing laboratory to ensure that necessary samples and validation work has been performed

Testing may not be possible in multiple pregnancies. In such cases contact the laboratory for discussion