1. Singleton pregnancy at risk of retinoblastoma following discussion with testing laboratory, where either the mother/father/previous child has a confirmed diagnosis of heritable retinoblastoma by genetic testing (ie maternal, paternal or de novo inheritance) AND
2. For paternal or de novo inheritance – DNA is available from both parents (and affected child where appropriate) OR
For maternal inheritance testing, DNA must be available from both parents and a previous child
(affected or unaffected confirmed genetically) and the parents must be non-consanguineous