Request / Find a Test Tool

The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

This tool allows clinical teams to search all of the genomic tests available to patients through the National Testing Directory. From here you can find out more details about each test and information about how to order them. These tests can only be ordered by clinical teams, if you are a patient looking to request a test please speak to your clinical team directly.

Inherited ovarian cancer (without breast cancer)

Clinical Indication ID & Name

R207

Inherited ovarian cancer (without breast cancer)

Test Group

Core

Specialties

Oncology Clinical Genetics Gynaecology

Test code

R207.1

Test name

N/A

Target genes

Inherited ovarian cancer (without breast cancer) (143)

Test scope

n/a

Test method/ technology

Small panel

Optimal Family Structure

n/a

Eligibility Criteria

1. High grade non mucinous epithelial ovarian cancer (EOC) at any age
OR
2. Epithelial ovarian cancer (EOC) AND
a. ≥1 first degree relative with EOC, OR
b. ≥1 second degree relative with EOC (intervening relative is male, OR female with BSO, OR female deceased) OR
c. ≥2 second / third degree relatives with EOC
3. Deceased affected individual (proband) where criteria 2 are reached (or family Manchester score of 20) and:
a. Appropriate tissue is available (tumour or normal) AND
b. No living affected individual is available for genetic testing

NOTE: The proband’s cancer and majority of reported cancers in the family should have been confirmed

Test code

R207.2

Test name

N/A

Target genes

Inherited ovarian cancer (without breast cancer) (143)

Test scope

n/a

Test method/ technology

MLPA or equivalent

Optimal Family Structure

n/a

Eligibility Criteria

1. High grade non mucinous epithelial ovarian cancer (EOC) at any age
OR
2. Epithelial ovarian cancer (EOC) AND
a. ≥1 first degree relative with EOC, OR
b. ≥1 second degree relative with EOC (intervening relative is male, OR female with BSO, OR female deceased) OR
c. ≥2 second / third degree relatives with EOC
3. Deceased affected individual (proband) where criteria 2 are reached (or family Manchester score of 20) and:
a. Appropriate tissue is available (tumour or normal) AND
b. No living affected individual is available for genetic testing

NOTE: The proband’s cancer and majority of reported cancers in the family should have been confirmed

Commissioning group

Core

Overlapping idications

• M2 Ovarian carcinoma should be used for somatic testing

Address for samples/request forms

North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH

Contact with queries

gos-tr.norththamesgenomics@nhs.net

Supporting documents

n/a

Education resources

n/a

Service updates

n/a

Request form download

RD Non-WGS - Record of Discussion

Consent record

See consent guidance in test request form

Sample requirements

See sample guidance in test request form