Clinical Indication ID & Name
ALK Positive Anaplastic Large Cell Lymphoma
Test Group
Haematology
Specialties
Test code
M182.1
Test name
t(2;5)(p23;q35) ALK-NPM1 FISH/RT-PCR
Target genes
ALK-NPM1
Test scope
Structural variant detection
Test method/ technology
FISH/Simple targeted mutation testing
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M182.2
Test name
ALK rearrangement FISH
Target genes
ALK
Test scope
Structural variant detection
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M182.3
Test name
WGS Germline and Tumour
Target genes
All including burden / signature
Test scope
All variant types
Test method/ technology
WGS
Optimal Family Structure
n/a
Eligibility Criteria
For paediatric cases only
Test code
M182.4
Test name
Multi-target NGS panel - structural variant (ALK-NPM1, other ALK rearrangements)
Target genes
ALK-NPM1, ALK
Test scope
Structural variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH
Contact with queries
Supporting documents
n/a
Education resources
n/a
Service updates
n/a
Request form download
n/a
Consent record
See consent guidance in test request form
Sample requirements
See sample guidance in test request form