Clinical Indication ID & Name
ALK Negative Anaplastic Large Cell Lymphoma (Including Primary Cutaneous Subtypes)
Test Group
Haematology
Specialties
Test code
M112.3
Test name
IRF4/DUSP22 rearrangement FISH/RT-PCR
Target genes
DUSP22
Test scope
Structural variant detection
Test method/ technology
FISH/Simple targeted mutation testing
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M112.4
Test name
TP63 rearrangement FISH/RT-PCR
Target genes
TP63
Test scope
Structural variant detection
Test method/ technology
FISH/Simple targeted mutation testing
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M112.5
Test name
WGS Germline and Tumour
Target genes
All including burden / signature
Test scope
All variant types
Test method/ technology
WGS
Optimal Family Structure
n/a
Eligibility Criteria
For paediatric patients only
Test code
M112.6
Test name
Multi-target NGS panel - structural variant (IRF4/DUSP22, TP63)
Target genes
IRF4/DUSP22, TP63
Test scope
Structural variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH
Contact with queries
Supporting documents
n/a
Education resources
n/a
Service updates
n/a
Request form download
n/a
Consent record
See consent guidance in test request form
Sample requirements
See sample guidance in test request form