The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

This tool allows clinical teams to search all of the genomic tests available to patients through the National Testing Directory. From here you can find out more details about each test and information about how to order them. These tests can only be ordered by clinical teams, if you are a patient looking to request a test please speak to your clinical team directly.

Clinical Indication ID & Name

R65

Aminoglycoside exposure posing risk to hearing

Test Group

Core

Specialties

Test code

R65.1

Test name

N/A

Target genes

MT-RNR1 1555A>G

Test scope

n/a

Test method/ technology

Targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Significant exposure to aminoglycosides posing risk of ototoxicity
This indication would be relevant to:
1. individuals with a predisposition to gram negative infections for example due to known respiratory disease (e.g. bronchiectasis, cystic fibrosis) or due to structural or voiding genitourinary tract disorders,
OR
2. individuals with hearing loss who have been exposed to aminoglycosides

Commissioning group

Core

Overlapping idications

• R67 Monogenic hearing loss should be used in individuals with unexplained hearing loss

Address for samples/request forms

North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH

Contact with queries

gos-tr.norththamesgenomics@nhs.net

Supporting documents

Rare Disese WGS Clinician pack

Education resources

n/a

Service updates

n/a

Request form download

RD Non-WGS - Record of Discussion

Consent record

See consent guidance in test request form

Sample requirements

See sample guidance in test request form

Request / Find a Test Tool