Research
Research plays a vital role in improving our understanding about the role of genomics in the onset, progression, heritability and treatment of disease.
We’re committed to working with Genomics England, the National Institute for Health and Care Research (NIHR) and other partners to support genomic research projects in the region.
National NHS Genomics Research Collaborative
We contribute to the national NHS Genomics Research Collaborative, which has been set up to facilitate genomic research and development on a national scale.
The NHS GMS Research Collaborative is a partnership between the NHS GMS, Genomics England and the National Institute of Health and Care Research (NIHR) and is supported by a steering committee – an operational group which will review and give feedback on research proposals that require support from the NHS GMS. It will also rapidly evaluate the capacity, capability, and resource, of the NHS GMS to support research.
You can find out more about the collaborative and how to make a submission.
Research in the GOSH Rare Disease Laboratory
Our rare disease laboratory at GOSH has a core team of researchers, funded by the GOSH NIHR Biomedical Research Centre and various grants. The group comprises clinical scientists, post doctoral fellows, Clinical fellows and social scientists and works at the interface of translating research into clinical practice and is internationally renowned for translating research in prenatal diagnosis into clinical service. Current workstreams include;
- extending diagnoses in the 100,000 Genomes project
- applying new molecular technologies to improve prenatal diagnosis of monogenic disorders including non-invasive pre-natal diagnosis and rapid fetal exome sequencing
- developing methods of informed choice of sequencing testing both in the pre- and postnatal setting
- evaluating the experiences of parents and professionals with prenatal exome sequencing and examining the national implementation of this service.
Research in the Clinical Genomics Service at the Royal Marsden
Working closely with experts in oncology at The Royal Marsden and across the North Thames GMS, our cancer hub is working to bring novel testing to patients sooner, directing treatment strategies personalised to the patient.
Through their innovative genomic practice, the team have had successful collaborations in new clinical trials, especially in sequencing of circulating tumour DNA from liquid biopsies for colorectal cancer (TRACC), breast cancer (PEARL) and paediatric cancer (CRUK Stratified Medicine).
The team also collaborate with pharmaceutical companies and have experience in delivering large national projects, such as 100,000 Genomes Project and programmes supported by Cancer Research UK and the Institute of Cancer Research, whilst leading in genomic profiling of cancer patients.
